Antidepressants That Cause Weight Gain

It seems that it is impossible to find antidepressants that don’t cause weight gain due to the high concentration of medications that cause side effects.

For those who are suffering from depression, antidepressant will be your first step towards your road of freedom and recovery. Unfortunately, they will also need to face other problems such as weight gain.

At least 25% of the people taking antidepressants such as the SSRI drugs have been reported to increase their total weight to up to 10lbs.

Brands of Antidepressants That Cause Weight Gain

While people respond differently to the treatment, there are some brands of antidepressants that cause weight gain. Here are some of them.

TCA (Tricyclic Antidperessants)

TCA or also known as cyclic antidepressants that cause weight gain. This medication may include trimipramine, protriptyline, nortriptyline, imipramine, doxepin, desipramine, amoxapine, and amitriptyline.

This is one of the very first drugs that were approved to help in treating depression. These drugs are no longer prescribed that often since the newer types of medication will lead to lesser side effects.

Based on the study conducted last 1984, gaining weight is one of the major reasons why people choose to stop taking this medication.

Nowadays, TCA can still be prescribed to individuals who are not responding positively to the other antidepressant medications.

MAOI (Monoamine Oxidase Inhibitor)

The MAOI medications are some of the initial type of antidepressants drugs that were developed. MAOI antidepressants that cause weight gain include tranylcypromine, isocarboxazid, and phenelzine.

Due to some concerns on the safety of the patients, this medication will only be prescribed when other types of antidepressants are not working.

However, the latest development of MAOI showed an outstanding result. The selegiline is one of the antidepressants that don’t cause weight gain.


SSRI is perhaps the most common prescribed drugs for people suffering from depression. However, long-term use of this medication will actually result to weight gain.

Although there are some of the SSRI antidepressants that don’t cause weight gain, study shows that it will still lead to weigh gain after a long-term use.

Paroxetine is the SSRI drug that is commonly associated with the sudden increase of weight.

Atypical Antidepressants

Mirtazapine is one of the atypical antidepressants that cause weight gain. Compared to other types of drugs, the study shows that it will increase the appetite o the user more that will lead to a sudden increase on weight.

Still, Mirtazapine will less likely lead to weight gain when compared with TCA. It may also lead to other side effects which include sexual dysfunction, vomiting, and nausea.

Antidepressants that don’t cause weight gain

In case you want to avoid these depressants, you may want to choose the antidepressants that don’t cause weight gain.

Some of the medications that will not lead to increase on weight include selegiline, vilazodone, citalopram, and vortioxatine.

There are also antidepressants that will lead to the right amount of weight loss such as buproprion, and duloxetine.

Ask your doctor about your particular needs, and he will prescribe the medication that will address your needs and preference.

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